Sebastian Caliri

Investment Team
San Francisco, CA
[overview]

Sebastian leads 8VC's healthcare team, investing in and building health-IT and health services businesses, alongside work in other sectors of the economy.

Prior to 8VC, Sebastian led the healthcare division at Palantir where he helped numerous insurance, pharmaceutical, provider, and government clients solve their hardest data analysis problems.

Outside of work, Sebastian is an avid reader, amateur artist, and loves long runs on the Embarcadero and backpacking in the Sierra.

Sebastian completed a year of the MD program at Stanford University and holds a BS and MS, magna cum laude, in Molecular Biophysics & Biochemistry from Yale University.

[Q&A]
Posts
News
Jan 27, 2025

A Healthcare Excellence Agenda for the New Administration

In 2023, the U.S. federal government spent a staggering $1.5 trillion on healthcare, yet Americans are becoming unhealthier by key measures like obesity, maternal mortality, and life expectancy. This unsustainable trajectory not only undermines public health but threatens the fiscal future, with healthcare spending growing faster than the economy and consuming nearly 30% of the federal budget. Despite challenges, the path forward lies in incentivizing innovation, reforming payment structures, liberating healthcare data, and reducing fraud. By fostering a competitive, entrepreneurial healthcare system and embracing cutting-edge technologies like AI, the U.S. has the potential to improve health outcomes while controlling costs and ensuring a brighter, healthier future.

Posts
News
Jan 27, 2025

A Healthcare Excellence Agenda for the New Administration

In 2023, the U.S. federal government spent a staggering $1.5 trillion on healthcare, yet Americans are becoming unhealthier by key measures like obesity, maternal mortality, and life expectancy. This unsustainable trajectory not only undermines public health but threatens the fiscal future, with healthcare spending growing faster than the economy and consuming nearly 30% of the federal budget. Despite challenges, the path forward lies in incentivizing innovation, reforming payment structures, liberating healthcare data, and reducing fraud. By fostering a competitive, entrepreneurial healthcare system and embracing cutting-edge technologies like AI, the U.S. has the potential to improve health outcomes while controlling costs and ensuring a brighter, healthier future.

Posts
Oct 31, 2024

The AI Services Wave: Lessons from Palantir in The New Age of AI

Last month, the first company I co-founded, Palantir, joined the S&P 500. For most of 20 years, the naive mainstream view of Palantir was that it was a “glorified consultancy” – a services firm and not a real tech innovator building SaaS “products” or “platforms”. To dismiss Palantir early on was short-sighted, given they’d hired some of Silicon Valley’s top tech talent, but it was based on a factual observation: unlike most software businesses, many of our engineers spent significant time working alongside our customers. We called this team “Forward Deployed Engineers”, and they obsessed over the intricacies of our customers’ daily work, business models, and pain points. 

Posts
Oct 31, 2024

The AI Services Wave: Lessons from Palantir in The New Age of AI

Last month, the first company I co-founded, Palantir, joined the S&P 500. For most of 20 years, the naive mainstream view of Palantir was that it was a “glorified consultancy” – a services firm and not a real tech innovator building SaaS “products” or “platforms”. To dismiss Palantir early on was short-sighted, given they’d hired some of Silicon Valley’s top tech talent, but it was based on a factual observation: unlike most software businesses, many of our engineers spent significant time working alongside our customers. We called this team “Forward Deployed Engineers”, and they obsessed over the intricacies of our customers’ daily work, business models, and pain points. 

Posts
News
Jan 30, 2024

A Survey Of Large Language Models Accelerating Healthcare Businesses Today

Posts
News
Jan 30, 2024

A Survey Of Large Language Models Accelerating Healthcare Businesses Today

Video
Aug 8, 2022

The Potential of Psychedelic Medicine & Why Medical School Is Broken

Video
Aug 8, 2022

The Potential of Psychedelic Medicine & Why Medical School Is Broken

Posts
Jun 2, 2020

Why you should build in primary care: a layman’s guide to risk delegation

A profound shift in how primary care is financed is opening up opportunities for entrepreneurs to transform the landscape of American healthcare. Who will start the next Humana?

Posts
Jun 2, 2020

Why you should build in primary care: a layman’s guide to risk delegation

A profound shift in how primary care is financed is opening up opportunities for entrepreneurs to transform the landscape of American healthcare. Who will start the next Humana?

Posts
Apr 30, 2020

What happened to the future of healthcare?

Why health IT has under-delivered, and how we can recover the promise of the 2010s.

Posts
Apr 30, 2020

What happened to the future of healthcare?

Why health IT has under-delivered, and how we can recover the promise of the 2010s.

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